Michelle Pfeiffer, 50: The all-American California beauty has become a talented actress in both dramas and comedies (personal favorites include "Married to the Mob," "The Fabulous Baker Boys," and "Dangerous Liaisons"). In 2007 she had a double-whammy comeback of sorts, with riveting roles in "Hairspray" and the underrated "Stardust." And she's a devoted mom and longtime Hollywood wife to writer David E. Kelley. Sprinkled with stardust, indeed.